Term
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Definition
GnRH agonist that stimulates short term secretion of LH/FSH. Continued exposure interrupts pulsitivity and actually inhibits LH/FSH.
Used for prostate cancer, precocious puberty, uterine leomyoma, endometriosis
non FDA: BPH, Breast, PMS |
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Term
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Definition
antifungal agent that at high doses inhibits steroidogenic p450s (aldo, corto, testo... mainly testosterone).
unapproved for prostate cancer
causes shorterm rise testosterone, decreased libido |
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Term
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Definition
Competitive specific inhibitor of type II 5-alpha-reductase of the prostate, seminal vesicles, epididymes and hair follicles(BLOCKS DHT NOT T)
Indications: Prostate cancer, BPH and alopecia.
better tolerated than flutamide |
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Term
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Definition
Non-steroidal anti-androgen used as an anti-hormone in the treatment of prostatic carcinoma. Most effective when used as a combination with GnRH agonist Leuprolide
USed for prostate cancer and nonapproved for BPH |
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Term
| Testosterone replacement therapy |
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Definition
Normally delivered as a topical skin gel for congenital/aquired hypogonadism, breast carcinoma post menopausal women.
NonFDA approved: gender change, aids wasting, anemia in renal failure |
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Term
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Definition
| One short enzymatic step from testosterone. Only recently banned by the MLB. |
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Term
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Definition
Human Chorionic Gonadotropin. Same Alpha subunit as LH/FSH. Binds and activates LH receptor and marketed (illegally) over internet for weight loss. BINDS LH-R
Assisted in fertility to mimic LH surge. NonFDA: bodybuilding/weightloss
may cause anovulation, hirsiutism, cliteromegaly,
promotes T from leydig |
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Term
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Definition
| Block negative feedback that delays LH surge. This broadens the surge and increases the potential that a dominant follicle will be in position to ovulate. |
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Term
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Definition
| Blocks FSH production and the LH Surge effectively inhibiting ovulation. |
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Term
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Definition
| An anti-estrogen used block negative feedback of estrogen at the hypothalamic-pituitary axis and broaden the LH surge. This is used to increase the changes of ovulation. Aromatase inhibitors can be used for the same purpose but are not FDA approved for this purpose. |
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Term
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Definition
aromatase inhibitor for breast cancer and post menopause.
May cause OSTEOPOROSIS
blocks peripheral estrogens |
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Term
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Definition
Dopamine Receptor Agonist for hyperprolactinemia in infertility.
NAUSE/VOMIT/HEADACHE.
Not a cure for adenoma |
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Term
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Definition
| 1st generation SERM in hormone sensitive breast cancer, can increase severity outgrowth, anti-estrogen breast, estrogenic bone |
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Term
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Definition
RU486: steroidal anti-glucocorticoid and progesterone. blocks ovulation and cuases abortion. CONTRAIND CORTICOSTEROIDS.
uterine leomyoma, breast/uterine cancer, can induce labor |
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Term
| Medroxyprogestone acetate |
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Definition
| Progesterone agonist in contraception and HRT. SE = pregnancy and breast cancer. Inhibits uterine hyperplasia induced by E2. |
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Term
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Definition
| Estrogen Receptor Agonist: for contraception and hormone replacement therapy. Increased risk of uterine and breast cancer. stabilizes bone demineralization and blocks ovulation. |
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Term
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Definition
| Progestin and weak anti-androgens by binding to receptor. USED FOR HIRSUTISM. Raises serum T levels (gynocarmastia). rarely used alone |
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