Term
| Leukocytosis with numerous blasts, myeloperoxidase negative-prognosis? |
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Definition
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Term
| BM failure, blasts in blood, most peroxidase positive, >90% blasts in BM |
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Definition
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Term
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Definition
| m2, better prognosis, responds to therapy |
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Term
| hypergranular promyelocytes w/ auer rods |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| >20% myeloblasts, >20% monoblasts w/ myelocyte and monocyte differentiation |
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Definition
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Term
| inv 16 or translocated 16 |
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Definition
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Term
Translocations deletions w/ 11 - prognosis
extra medullary involvement, significant risk of meningeal involvement |
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Definition
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Term
| patient presents w/ profound anemia- prognosis |
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Definition
| m6 (erythroleukemia)-poor |
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Term
| increased incidence in down syndrome <3 |
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Definition
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Term
| extra medullary involvement seen w/ which 2 |
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Definition
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Term
| mutations in Flt3 common (although seen in others), regulates survival, proliferation and differentiation of primitive hematopoetic progenitor cells |
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Definition
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Term
| macrocytic anemia for years, noted loss of 5, 7 or 8, now blasts in blood |
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Definition
| 2ndary AML (30% of myelodysplastic syndrome become AML) |
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Term
| Gemtuzumab ozogamicin is? |
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Definition
| recombinant humanizeed IgG against CD33- for AML w/ CD33 positive |
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Term
| Induction therapy for AML? |
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Definition
| anthtracycline (doxorubicin) + cytarabine |
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Term
| myelodysplastic syndrome - scoring system based on (3) |
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Definition
| percent BM blasts, specific karyotypic abnormalities, number of CYTOPENIAS |
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Term
| 5 azacytidine and decitabine -for? interfere w/ ? |
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Definition
| for myelodysplasia, interfere w/ DNA hypermethylation, un silence previously silenced regulatory genes |
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Term
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Definition
| 5q deletions, significant and prolonged improvements on bloodcounts, as well as decrease or disapperance of abnormal karyotype |
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