Term
rate limiting step of OH synthesis/cofactor?
What does it produce? |
|
Definition
alcohol dehydrogenase ADH
NAD
Acetaldehyde and NADH |
|
|
Term
| secondary metabolism orgnas |
|
Definition
|
|
Term
| what is the Mellanby Effect? |
|
Definition
| impairment is greater at a given blood alcohol level when BAC is increasing than for the same BAC when the blood alcohol level is falling |
|
|
Term
| GABA receptors when OH is present |
|
Definition
| enhanced capacity to bind |
|
|
Term
|
Definition
|
|
Term
| when do symptoms of OH w/d appear? |
|
Definition
12-72 last drink
peak effects 24-48 hrs
recovery 5-7 days |
|
|
Term
|
Definition
| chlorodiazepoxide or diazepam |
|
|
Term
|
Definition
| low to moderate doses: vasodilation/hypothermia |
|
|
Term
| effect of OH on GI/liver tract |
|
Definition
fatty degeneration--cirrhosis- portal HTN
erosive gastritis |
|
|
Term
|
Definition
| gynecomastia and testicular atrophy |
|
|
Term
| how to treat acute OH ethanol intoxication |
|
Definition
supportive care
look out for diabetic coma |
|
|
Term
| primary features of fetal alcohol syndrome |
|
Definition
| microcephaly, prenatal growth deficiency, and short palpebral fissures |
|
|
Term
| mech of action for Disulfiram |
|
Definition
inhibits ALDH
leading to accumulation of Acetaldehyde |
|
|
Term
| what is acetaldehyde syndrome |
|
Definition
vasodilation
severe headache
chest pain
blurred vision
nausea |
|
|
Term
| mech of action for Naltrexone |
|
Definition
blocking of central reward pathways
**less side effects than disulfriam** |
|
|
Term
|
Definition
muscle weakness
euphoria
suppression of inhibitions
induce retinal damage |
|
|
Term
| this should be looked for in methanol poisoning |
|
Definition
metabolic acidosis w/anion gap
fixed dilated pupils
retinal damage |
|
|
Term
| DOC to treat methanol poisoning |
|
Definition
|
|
Term
| mech of action for fomepizole |
|
Definition
| competitive inibitor of alcohol dehydrogenase |
|
|
Term
| what are the metabolic products of methanol |
|
Definition
| formaldehyde and formic acid |
|
|
Term
|
Definition
| blunt an individual's perception of ethanol impairment |
|
|
