Term
| catehhcoalmien duraiton of acctions |
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Definition
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Term
| indirect acting syptahmoemtics doa |
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Definition
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Term
| epinephrine recetor action |
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Definition
| acts o all of them equally |
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Term
| norepinerphien receptor action |
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Definition
| a1 and a2 equal , but more sectie for b1 than b2 |
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Term
| isoporotenerol rcpetor action |
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Definition
| almost ompletly b, b1 and two equlaly agonism |
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Term
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Definition
| agonism of b1 more ehtan b2 but much mroe htan alpha |
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Term
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Definition
| mostly dopamine but can at high conenctraiton activate beta nad then alpha recpetors |
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Term
| phenylperhine recpetor action |
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Definition
| a1 mroe than alpha2 no beta repcetor action, agonist |
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Term
| clonidine receptor action |
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Definition
| agonism of alpha 2 more than alpha 1 which ism uch much mroe than beta |
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Term
| albuterol, tritodrine receptor action |
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Definition
| beta2 much moreh than b1 , no alpha recpetor action |
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Term
| indirect sympathommemtic tyeps |
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Definition
| amphetamines, methyphenidate, tyramine, cocaine. all act on alpha and beta |
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Term
| mixed symapthmiemtic types |
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Definition
| they are indirect plus direct alpha and beta. ephedrine ,and psueodepehedrine |
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Term
| two oh groups attack serine residues . on theo ther side, amino group interacts iwth conserved aspartate. |
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Definition
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Term
| alpha selctive agonist main effect |
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Definition
| increse in blood pessure due to vascoconstriction |
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Term
| b selective agonist main effect |
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Definition
| increasei heart rate adn bp decrease |
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Term
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Definition
| some incresein bp and some incresei n heart rate |
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Term
| epinephrine clinical uses |
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Definition
| anaphylatic shock , acuste asthmatic atacks, prologn aciton of lcoan anesthetics, topical hemostatic agent, cardiac arrest |
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Term
| epinephrine adverse effects |
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Definition
| hypertension, arrythmias, angina, encrsosis folowing extravasiation |
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Term
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Definition
| for strong activation fo beta recpetors |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| phenylephrine clinical use |
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Definition
| vasoconstirctive effects tot reat hypotension and shock. Usedi n nasal decongestion and opthalmic effect fo mydriasis |
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Term
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Definition
| penetrates cns, inhibiting ysmpathetic output. Use in hypertension (causes hypotension) .DIminish craving in narotis nad alcohol |
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Term
| albuterol ritodrine clincial use |
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Definition
| used in asthma for bronchodilation . inhalers tom inimzie systemtic effects |
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Term
| amphetaamine metylphenidate clincal cuse. |
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Definition
| readily enters CNS, release catecholamiensin cluding dopamine. CNS elevation fo mood and elertness and supresison fo appetetipe. USed for narcolepsy, weight loss, and ADHD |
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Term
| amphetaamine metylphenidate clincal cuse. |
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Definition
| readily enters CNS, release catecholamiensin cluding dopamine. CNS elevation fo mood and elertness and supresison fo appetetipe. USed for narcolepsy, weight loss, and ADHD |
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Term
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Definition
| vasoconstriciton and loca anesthesia, side effects inclusdeh yeprtensive response |
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Term
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Definition
| found in food, improatnt if mao inhibitor present, causes ne-like hyperetensive response |
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Term
| ephederine , psudoepehrdrine |
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Definition
| cns penetration , midlstimulants. Long DOA. - used as nasald econgestants and bronchodilators. |
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Term
| nonspeicifc alpha blockers effect |
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Definition
| a1/a2 blockers, predominant effect is vasodilation , reflex tachycardia by decresed a2 medaited feedback inhibtion , blunting hypotensive rsone by the increased cardiac output. |
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Term
| nonspecifica lpha blockers adverse effects effect |
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Definition
| orthostatic hypotensionn, nasal stuffifnes,s tachycardia . |
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Term
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Definition
| requries bioactiation, covalent and irreversible adrenergic antagonist- treatment of pehochromcyotoma |
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Term
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Definition
| competitivei nhbitor, used tor pheochromocytoma. |
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Term
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Definition
| decrese bblodo presusre with less reflex stimaulti on of heart rate by decreasing preload and afterload. USedt o treat hypertension and used to promote urine flow (BPH). |
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Term
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Definition
| used for hypternion and BPH, a1 blocker |
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Term
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Definition
| used for hypternion and BPH, a1 blocker |
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Term
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Definition
| a1 blocker. promote urien flow in bph with little effects on blood pressure |
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Term
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Definition
| no real effects onarterial pressure, more useful for decreasing ccontractility |
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Term
| effects of beta blockeers |
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Definition
general effects no cardioselectivity .
cadiovascualr: decrease heart rate and mycoradial conrtactility. Short term - decreasing cardiac output but increasing peripheral restiatnace (due to b2 blockage), howeverin logner term peripherla restiatnce normalizes resulting in decreased myocradial o2 consumption.
BP0 no effect on normal, decrase htn in hyeprtensives.
pulmonary- b2 antagonism of bronchodilation. Dangerous in COPD and asthma.
eye- decrease aqueous humor produciton form ciliary epithelium.
metabolic- blocks glucose mobilziation- , slows loplysis, increase vldl and lowesr hdl (unfavorable) |
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Term
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Definition
relatively specific for b1 and b2. WIth b1 mroe than b2 knwon as cardioselelctive (less effects on lungs)
2. partial agonist activity (ISA- intrisnic symapthomimetic activity). useufl for patient with sympomatic bradicyardia or ashtam with pure antagonsits.
local anaesthetic properties- undesirable for eye (membrane stabiilizing activity). |
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Term
| beta blcoker pharacokinetics- |
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Definition
| well absorbedafter oral administration |
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Term
| b blocker therapuetic uses |
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Definition
| angina, hyperentsion, supraventricualr and ventricualr arrythmias, myocardial infarction , hyperthyroidism (coutneracts b receptor upregulation). Glaucoma (decreased produciton of aques humor). prevention of migraen (prohpylactically) and tremors. and Heart failure |
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Term
| B blocker effects / contraindications |
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Definition
heart failure, bradycardia, COPD and asthma. Abruupt withdrawl leadinds to angina and sudden death due to enhacne beta sensitity.
Blutn recovery form hypolgycemia may also mask ysmtpoms .
adverse plasma lipoporiten profiels.
CNS effects- sleep disturbances and depresison. |
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Term
| B blocker effects / contraindications |
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Definition
heart failure, bradycardia, COPD and asthma. Abruupt withdrawl leadinds to angina and sudden death due to enhacne beta sensitity.
Blutn recovery form hypolgycemia may also mask ysmtpoms .
adverse plasma lipoporiten profiels.
CNS effects- sleep disturbances and depresison. |
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