Term
| What drugs cause most death? |
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Definition
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Term
| When does addiction behavior become a chronic disease? |
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Definition
| after a person is hooked, adidiction becomes a chronic disease with relapses and remissions just as other chronic diseases such as hypertension, diabetes, arthritis, or asthma |
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Term
| Which drug as highest risk of dependency |
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Definition
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Term
| with what drugs show increased in dopamine in NA? |
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Definition
| nicotine, alcohol, opiates, cocaine |
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Term
| with more morphine (higher doses), more dopamine in NA? |
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Definition
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Term
| What is the brain dopamine system? |
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Definition
| VTA/SN --> NA--> prefrontal cortex or cingulate gyrus |
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Term
| what is cocaine's mechanism? |
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Definition
| cocain blocks the dopamine receptor--so that when dopa is released, it cannot be reuptaked |
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Term
| what is major variable influencing progression to addiction with the agent (drug)? |
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Definition
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Term
| What are inherited factors for initial drug exposure? |
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Definition
| dose-plasma levels (absorption and disposition), flushing response, perception of pleasant effect, rapidity of tolerance development |
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Term
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Definition
| a reduction in drug effect with repeated admin |
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Term
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Definition
| refers to the common tolerance seen within drug classes so that tolerance to one implies tolerance to another |
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Term
| what are the affects of acquired tolerance? |
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Definition
| pharmakinetics, pharmadynamics, behavioral tolerance, conditioned tolerance |
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Term
| What is cross tolerance used for? |
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Definition
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Term
| what do you use for heroin? |
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Definition
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Term
| what med do you use for EtOH detox? |
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Definition
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Term
| Is a withdrawl syndrome a sign of addiction? |
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Definition
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Term
| Is tolerance/withdrawl nec or sufficient for addition? |
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Definition
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Term
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Definition
| reverse of tolerance (with stimulants--increased effects with repeated, spaced dosing) |
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Term
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Definition
| an irresistible impulse to act, regardless of rationality of teh motivation |
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Term
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Definition
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Term
| what is the most rapid method for drug admin? |
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Definition
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Term
| How long can physical changes take to get back "to normal"? |
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Definition
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Term
| why a conditioned reponse--on a cellular level? |
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Definition
| changes in gene transcription |
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Term
| What is a learned response? |
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Definition
| response in absence of a dose of drug--brain activation--cued, induce cocain craving |
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Term
| which brain structures are affected by cocaine? |
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Definition
| limbic structures like Cingulate gyrus and amygdula |
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Term
| What is the current "rewards system hypothesis?" |
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Definition
| Drugs of abuse tend to give strongest activation to reWARDS CENTER, so repeated use will have strongest activation of rewards center--hijakc system developed for reinforcement of normal rewards has been overtaken |
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