Term
What is the treatment for Unstable Angina/Non-ST segment Elevation Myocardial Infarction (US/NSTEMI)
(it's an acronym)
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Definition
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Term
| What does MONA + GAP-BA stand for? |
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Definition
M: Morphine
O: Oxygen
N: Nitrates
A: ASA
G: GP IIb/IIIa receptor antagonists
A: Anti-coagulants
P: P2Y12 Inhibitors
B: Beta - blockers
A: ACE-Inhibitors
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Term
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Definition
produces arteriolar and venous dilation; prompts a decrease in myocardial O2 demand; pain relief |
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Term
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Definition
Dilates coronary arteries and improves collateral blod flow; decrease cardiact oxygen demand by decreased preload
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Term
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Definition
| Inhibits platelet aggregation by inhibiting TXA2 |
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Term
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Definition
Statment. Not a question.
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Term
| What is the purpose of the IIb/IIIa receptor antagonists? |
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Definition
Blocks fibrinogen binding to the GPIIb/IIIa receptors on platelets, preventing PLT aggregation |
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Term
| Purpose of the P2Y12 inhibitors? |
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Definition
| inhibitor of the P2Y12 receptor on platelets |
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Term
| purpose of beta-blockers? |
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Definition
| blocks beta receptors on the heart; cardioprotective |
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Term
| Purpose of the ACE-Inhibitors? |
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Definition
Inhibits angiotensin converting enzyme and blocks the production of angiotensin II; prevents cardiac remodeling; decreased preload and afterload
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Term
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Definition
| Statement. Not a question. |
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Term
| What are the medications to avoid in UA/STEMI? |
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Definition
Discontinue all NSAIDs (including COX-2 inhibitors) due to their risk of mortality, reinin fraction, hypertension, and heart failure in these patients
IR form of DHP calcium channel blocker (e.g. nifedipine) should not be used in absence of a beta-blocker
IV fibrinolytic therapy is not indicated in patients without acute ST - segment elevation or left bundle branch block
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Term
| How do GP IIb/IIIa receptor antagonists work? |
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Definition
Reversibly blocks platelet aggregation, preventing thrombosis
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Term
| name some GP IIb/IIIa receptor antagonists |
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Definition
Abciximab (ReoPro)
Eptifibatide (Integrillin) |
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Term
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Definition
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Term
| Brand name of Eptifibatide |
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Definition
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Term
Should the vials for abciximab and eptifibatide be shaken upon reconstitution? |
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Definition
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Term
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Definition
| Statement. Not a question. |
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Term
| How do P2Y12 inhibitors work? |
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Definition
| Inhibit P2Y12 on the ADP receptor of platelets |
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Term
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Definition
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Term
| Brand name for clopidogrel |
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Definition
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Term
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Definition
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Term
| Black box warning for clopidogrel |
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Definition
| Diminished effectiveness in poor metabolizers |
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Term
| Black box warning for prasugrel |
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Definition
| can cause significant and fatal bleeding |
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Term
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Definition
| Statement. Not a question. |
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Term
Clopidogrel is a prodrug metabolized by CYP 2C19. Avoid concomitant use with strong or moderate 2C19 inhibitors. Name some 2C19 inhibitors. |
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Definition
Omeprazole, esomeprazole, cimetidine, fluconazole, ketoconazole, voriconazole, fluoxetine, fluvoxamine
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Term
Clopidogrel and Prasugrel. Which one has the highest risk of increasing INR in patients on warfarin? |
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Definition
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