Term
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Definition
| AML: granules stickign together, auer rods and more cytoplasm. ALL: no auer rods with minaml cytoplasm. |
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Term
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Definition
| prolfieration uncontrolled, |
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Term
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Definition
| blcok in differentiation. |
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Term
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Definition
| 5q-, monosomy 7, trisomy 8, 11q23 |
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Term
| AML M3 marker/translocation |
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Definition
| PML-RARa (15:17 translocation), transciptional repressor- arrest of cellualr differentiation. ATRA causes diff and cell death of promyelcoytes |
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Term
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Definition
| cytogenetics, ISH, rt-cr. |
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Term
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Definition
| cd13,cd33, glycophorin (m6), platelet antigens (m7) |
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Term
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Definition
| b lienage: cd19, cd 22, cd10 plus/minus, srafce IG surfae Ig, and tdt- |
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Term
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Definition
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Term
| chloroma/granulocytic acoma |
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Definition
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Term
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Definition
| most common in children: regualr sypmtoms ofbm failure (nuetropenia, anemia, thrombocytopenia, organ infiltration.) plsu cns and testicular involvement. Nutropenic fevers Treatment: combination chemotherapy. Look at image. |
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Term
| ALL prognosis : sex, phoneotype, age, cytogetnetics, |
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Definition
| girls better prognosis, b-all>t ALL, child>adult/infant. Cyotgenetics: PH, 11q23 are poor markers. Hyperploidy is good marker. Good prognosis |
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Term
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Definition
| markers: cd13,cd33, myeloperoxidae, sudan , black,esterase, Auer Rods (image) . Secondary AML can delevop. Treatmetn: bad prognosis: chemo, itnermediate: transplatn optional, poor: definte transplant . For Aml 3 also give ATRA |
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Term
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Definition
| result of myelodysplasia previous chemotherapy, poor prognosis. |
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Term
| aml favorable markers (godo ones) |
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Definition
| t (8:21)- m2 , m3-15:17, eosonophillia-ivn16 , younger age, wbc <30,000 - these are favorable . |
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Term
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Definition
| older age, way higher wbc, if secondary in nature, deletion of five:7,, t (6;9) , t(9:22), chromosome 11 abnormality. acute monocytic luekemia- (m5) T (9:11). Flt3 trisomy 8 |
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Term
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Definition
| adult luekemia. clonality of the true HSC. Most asyptoamtic and diagnosed via cbc. Philadelphai chrososome, t9:22, bc-abl (defective apoptosis advantage). Able to transform to blastphase due to addition of molelcular changes. A lot of healthy white blodo cells produced. (slide) |
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Term
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Definition
| prevents atp dependant tyrosien phosphorylation of substrate. For treatmetn of oPh translcoation in CML. |
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Term
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Definition
| common in older patietns , more males. B cell disease, cells accumulate in traidtionalareas (blodo , bone marrow, liver spleen, lymph nodes). Diagnosis: asymptomatic, thouh also commonly presents with symmetrical lymphaedenoapthy. Hypoglobluiemic so have ifnections, also hemolytic anemia. lab findings: lymphocytosis ,smudge cells. Anemic (bm infiltartion). smudge cells , marekrs: cd5 ( t cell) , cd,19,20 (b cell) and cd 23 positive. |
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Term
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Definition
| rai: absolute lymphocytosis (0), lymphocytosis and absolute lymphocytsosis (0)nodes (1) lymphocytosis with spleen/liver (2), lymphocytotsis and anemia (3), lymphocytosis and thrombocytopenia (4). Binet staging based on hemoglobin, plasma cell numbeers, whetehr 3 lymph nodes are involved. |
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Term
| CLL prognosis: sex, binet, bm involvement, cytogenetics, vh Ig genes, LDH, cd38, zap70 |
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Definition
| binet A -G , binet,b,c-B, female-G , BM involvement-nodular-G, diffuse-B cytogenetics-13 chromosome deletin-good, b-trisomy 12, p53 mutation-b. vh Ig mutation-G, LDH elevated levels-B, cd38 presence-B, zap70 presence-B |
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Term
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Definition
| Just watch them if asymptomatic. No curative treatment. Only treat for lymph nodes if become painful, or if compress on important organs. Combinational chemotherapy based on patient. Monoclonal antibodies: can target cd20,cd52. |
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Term
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Definition
| cells feed on their microenvironment, microenvivonremtn growth factors actively promote prolfieration.. Pathobiology: presents as disease of bone marrow only : IgG in blood and urine , serum M protein spike. Osteolytic bone lesions due to osteoclast actiating factors released from malignant cells ... Disease pattern: remission followed by relapse , until eventually relapse for ood. Staging: serum macrolobulin and albumin levels (3 stages dpenednign on levels ) look at slide |
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Term
| multiple myeloma negative prognostic factors . |
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Definition
| generally bad prognosis to begin with. high ldh, chrosome 13 deletion, hypoploidy, t(4:14, 1416,7q-), kidney failure . , ciruclating palsma in bodo cells. |
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Term
| Multiple myeloma diagnosis |
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Definition
| clonal plasma cells in marrow/ plasmacytoma. 2. monclolonal protein in serum or urine. 3. organ related dysfunciton. |
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Term
| Multiple myeloma supportive therapies |
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Definition
| treat bone disease (bisphosphonphates), anemia, renal failure, and hypercalcemia. Autologous transplants increase life. When to start therapy:don’t strt until symptomatic. |
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Term
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Definition
| rapidly fatal diesease 20 percent blasts in BM |
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Term
| msot ommon luekemia in kids |
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Definition
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Term
| msot common leukemia in adults |
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Definition
| AML: granules stickign together, auer rods and more cytoplasm. ALL: no auer rods with minaml cytoplasm. |
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Term
| most common cause of leukemia |
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Definition
| age, rather than genetics. |
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Term
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Definition
| bcr-abl, in pre-b all and cml |
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Term
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Definition
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Term
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Definition
| 12:21 in preb all. FAVORABLE |
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Term
| actiavated ras oncogene poitn mutatino |
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Definition
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Term
| acute luekemia clinical manisfestatiosn |
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Definition
| included yperkalemia and hyperuricemia. Decreased nomral or elevated wbc. Organ inflitraion, includignginvial hypetrophy |
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Term
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Definition
| cd19, cd22 , tdt postivie always. Sometimes: cd10. |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| rapid release of itnracellualr contents. Leadgin to lifet hretenign concentrations. |
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Term
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Definition
| LUKEMIC OBSTRUCTION ANDI NFILTRATION: LUNGS AND CNS MSOT COMMON ORGANS. Aml-m3 and m5 . Treat rapidly and avoid transfusions |
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Term
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Definition
| occurs in all age groups but most commo nleukemia ina dults. Primary and secondary aml , simliar c lincial feaatures to ALL. |
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Term
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Definition
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Term
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Definition
| favorble- conventional chemotherpy interdmatie- tranpslant optional. Adverse- needwtranasplant. Idnuction chemo and consoloditiaon chemo, and maintenance . Give atra for aml m3. |
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Term
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Definition
| cml; additioanl molecular changes. |
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Term
| multiple myelomadisease progression |
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Definition
| several remission but eventually resistant disease and death |
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Term
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Definition
| some inceased in M protein , but no syptoms of MM, don’t treat unless diseasep rogression because good chance wont develop to malignancy. EVEn indolent MM is not terated, only start treatmetn with symptomatic mM. |
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Term
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Definition
| BASED ON morphology of AML (level of differentiation) |
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Term
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Definition
| cd 10 negative and tdt positive |
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Term
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Definition
| cd 5 positive (t cell marker) , cd 19, cd 20 , cd23 positive |
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