Term
| 3 types of protozan infxns |
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Definition
| ALT: amebiasis, leishmaniasis, Trypanosomiasis |
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Term
| Luminal Amebicides indicated for ASYMPTOMATIC intestinal infection |
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Definition
| -Diloxanide (B-CI during pregnancy) and Paramomycin |
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Term
| SE of diloxanide and Paramomycin |
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Definition
|
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Term
|
Definition
| Chloroquinine and dehydroemitine |
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|
Term
| DOC for C.Diff, trichomoniasis and giardiasis |
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Definition
| Mixed Amebicide Metronidazole |
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Term
| Dont use in 1st trimester, METALLIC taste, 50% relapse rate. |
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Definition
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Term
|
Definition
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Term
| Ifxn that causes skin sore and affects the liver and spleen via sandflies (co-infxn with HIV common) |
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Definition
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Term
| drug indicated for cutaneous and visceral leishmaniasis infxn |
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Definition
|
|
Term
| inhibits glycolytic enzymes and FA oxidation |
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Definition
| MOA of Sodium stibogluconate |
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|
Term
| prolonged QT and renal dysfunction |
|
Definition
| SE of Sodium stibogluconate |
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|
Term
| Best broad spectrum Anti-fungal and used for visceral leismaniasis (liposomal/lipid form$$$) |
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Definition
|
|
Term
|
Definition
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Term
| Drug to tx cutaneous Leishmaniasis (IM), Pneumocystic PNA in pt with sulfa allergy or african sleeping sickness |
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Definition
|
|
Term
| inhibits oxidative phosphorylation... can cause pain at injection shot or hypotension/tachycardia if giving IV |
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Definition
|
|
Term
| Infxn causing chancre at bite site, fever, HA, rash |
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Definition
|
|
Term
| American sleeping sickness and CHAGAS dz--> |
|
Definition
|
|
Term
| African Sleeping Sickness caused by |
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Definition
|
|
Term
| Drug used to tx AFRICAN sleeping sickness that has a SE of a crawling sensation during admin. |
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Definition
|
|
Term
| Drug used to tx american sleeping sickness and DOC for chagas dz |
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Definition
|
|
Term
| caused superoxide radical toxicity to parasite and host |
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Definition
|
|
Term
| may cause delayed hypersensitivity, GI issues, neuro issues |
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Definition
|
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Term
| pregnancy SAFE drug used to tx helminth (worm) infxn by inhibiting cholinesterase (Inc ACH--> paralysis) |
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Definition
| Pyrantal Pamoate (PP safe for Pregnancy) |
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|
Term
| drug used to tx helminth infsxn with Caution warnings during 1st trimester, if pt has IBS or liver dz |
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Definition
|
|
Term
| may cause GI or crytalluria/hematuria is used long term |
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Definition
|
|
Term
| Inhibits microtubule formation |
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Definition
| MOA of mebendazole and albendazole |
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Term
| broad spectrum anti-fungal NOT USED IN US |
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Definition
|
|
Term
| may cause alopecia and rash if used long term |
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Definition
|
|
Term
| anti-helminth drug that CANNOT be used in preggos, pt with renal or liver dz and may cause GI issues |
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Definition
|
|
Term
|
Definition
| Diethylcarbamazine citrate |
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|
Term
| may cause Mazzotti rxn (sev itching,, rash, tachy, HA) |
|
Definition
| Diethylcarbamazine citrate SE |
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|
Term
| DOC for onchocerciasis and strongyloidiasis |
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Definition
|
|
Term
| May cause a mazzott LIKE rxn |
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Definition
|
|
Term
|
Definition
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|
Term
| drug that tx tapeworm but should not be used with alcohol use |
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Definition
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|
Term
| the only abx that DOES NOT induce resistance |
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Definition
|
|
Term
| mutations, transduction, transformation, conjugation |
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Definition
|
|
Term
| bacteriostatics blocking bacteriocidal agents |
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Definition
|
|
Term
| use of 2 abx has BETTER effect than each drug alone |
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Definition
|
|
Term
| disadv to using combined microbials for broader range |
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Definition
| kills intestinal flora, get superinfxn and fungal growth |
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|
Term
| Abx preventing folic acid synthesis |
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Definition
|
|
Term
| prevent cell wall synthesis in actively growing bacteria |
|
Definition
| penicillin and cephalosporin |
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|
Term
|
Definition
|
|
Term
| 30s- protein synthesis inhibitor |
|
Definition
| aminoglycosides and tetracyclin |
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|
Term
| 50s- protein synthesis inhibitor |
|
Definition
| chlormphenicol and erythromycin |
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|
Term
|
Definition
| PAQC: penicillin, aminoglycosides, cephalosporin, quinolones |
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|
Term
|
Definition
| TEC: tetracyclines, erythromycin, chloramphenicol |
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|
Term
| IM admin given for G- infxn (binds 30S) |
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Definition
|
|
Term
| long acting, broadspectrum, bacterioSTATIC, DOC for PNA |
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Definition
|
|
Term
| may chelate bones and teeth or cause vestibular toxicity (N/V). dont give while baby's teeth are growing!! |
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Definition
|
|
Term
| last resort, broad spectrum, bacterioSTATIC used to treat a brain infxn |
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Definition
|
|
Term
| may cause GREY BABY SYNDROME (CI in newborns) |
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Definition
|
|
Term
| Used to tx G+ infn and can be combined with B-lactams or vanco |
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Definition
|
|
Term
| may cause Steven Johnson Syndrome |
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Definition
|
|
Term
|
Definition
|
|
Term
| 2 drugs that combined, tx G+ (LAST RESORT) and become synergistically bacterioCIDAL |
|
Definition
| dalfopristin and quinupristin |
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|
Term
| to tx G+ infxn, ONLY IF SEVER inxn so you dont build resistance |
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Definition
|
|
Term
| if you combine sulfonamide (S) and trimethromprim (S) they become |
|
Definition
|
|
Term
| inhibitors of tetrahydrofolate synthesis used to tx UTIs and resp infxns |
|
Definition
| STT: sulfonamides trimethoprim and co-trimoxazole |
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|
Term
| broad spectrum abx used to tx toxoplasmosis, IBD and conjunctivits. May cause stones and SJ syndrome |
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Definition
|
|
Term
| admin with folinic acid to prevent folate deficiency (MOA at difydrofolate reductase) |
|
Definition
|
|
Term
| DOC- broadspectrum abx for UTI |
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Definition
|
|
Term
| broadspecrtrum abx used in emprical therapy (CI in preggos and young kids) |
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Definition
|
|
Term
|
Definition
|
|
Term
| recipe for empirical therapy |
|
Definition
| 1. macrolide, 2. Fluoroquinolone 3. beta lactam(if no allergy to penicillin) |
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|
Term
| broadspectrum abx G->G+ given PO with a B-lactamase inhibitor (clavulonic acid & sublactam) |
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Definition
|
|
Term
| prophylactic semisynthetic broad band peni |
|
Definition
| ampicillin and amocxicillin |
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|
Term
| abx used to tx pseudomonas aeruginosa |
|
Definition
| Carbenicillin and Ticarbicillin |
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|
Term
| Abx given with Cilastatin |
|
Definition
|
|
Term
| abx used to tx serious G- infsn |
|
Definition
|
|
Term
| this drug was last resort for severe G+ infxn and MOA: binds D-Ala-D-Ala |
|
Definition
|
|
Term
| may cause redneck syndrom, be ototoxic or nephrotoxic |
|
Definition
|
|
Term
| inhibit bacterial cell wall synthesis |
|
Definition
| penicillins and cephalosporins (bacterioCIDAL) |
|
|
Term
| pt with active TB should be tx'd with |
|
Definition
|
|
Term
| topical ointment used to tx G+ inxn by affecting cell wall peptidoglycan syntehsis but is TOXIC |
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Definition
|
|
Term
| strongest activator of P450, TB drug. MOA is inhibiting DNA derived RNA polymerase |
|
Definition
|
|
Term
| may cause red colored urine, feces, tears, sweat but is safe |
|
Definition
|
|
Term
| 1st line TB drug always given in COMBO tx that inhibits mycolic acid from binding proteoglycans |
|
Definition
|
|
Term
| 1st line TB drug that may cause green&red optic neuritis |
|
Definition
|
|
Term
|
Definition
| REI- rifampin, ethambutol and isonazid |
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|
Term
|
Definition
| CASE: cycloserine, aminosalicyclic acid, squalamine, ethionamide |
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|
Term
| 2nd line TB tx CI in pt with ulcers or G6P deficiency |
|
Definition
|
|
Term
| Anti malaria drug that is prophylactic and targets the liver |
|
Definition
|
|
Term
| prophylactic anti malaria drug with long duration. kills plasmodium in the RBC |
|
Definition
| Chloroquine (CI in G6P-deh deficiency) |
|
|
Term
| cheapest anti-malaria drug that is used in combo with sulfonamide and targets the RBC |
|
Definition
|
|
Term
| anti malaria drug that ONLY AFFECTS RBC stage |
|
Definition
| MAT: mefloquine, artemisinin (best) and tetrandrine |
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|
Term
| anti fungals target this in growing cells |
|
Definition
|
|
Term
|
Definition
| garlic, oregano and lavender |
|
|
Term
| best anti-fungal for a severe systemic fungal infxn. bacteriocidal. causes nephrotoxicity |
|
Definition
|
|
Term
| Topical antifungal ampho-like. |
|
Definition
|
|
Term
| anti-fungal that is synergistic with amphoB (a prodrug) used to tx sever fungal infxn |
|
Definition
|
|
Term
| also an AntiCA drug, may cause BM depression, hair loss and liver abn |
|
Definition
|
|
Term
| Topical drug, Antagonistic with AmphoB and inhibits fungal P450 |
|
Definition
|
|
Term
| anti-fungal that crosses BBB, used to tx cryptoccal meningitis in AIDS pts |
|
Definition
|
|
Term
| oral anti-fungal given for nail/hair infxn |
|
Definition
|
|
Term
| drug used to treat PROPHYLACTIC influenza A and parkinson's Dz |
|
Definition
|
|
Term
| may cause epilepsy and neuro probs (in an OD) |
|
Definition
|
|
Term
| Amantadine analog used to tx Infuenza A and has less SE |
|
Definition
|
|
Term
| drug used to tx hemorrhagic fever w/i 10 days of onset, herpes, Hep, HIV etc but may cause hemolytic anemia |
|
Definition
|
|
Term
| Anti-viral given in HepB, Kaposi's sarcoma, NADPH oxidase def, to prevent Rhinovirus. May cause flu like sxs and neutropenia |
|
Definition
|
|
Term
| AIDS tx prodrug that is synergistic with anti-virals |
|
Definition
|
|
Term
| protease inhibitors what MUST be used in combo with protease inhibitors to prevent resistance. |
|
Definition
| SIR: squinavir, indinavir, ritonavir |
|
|
Term
| A combo of tetracyclin(s) + vancomycin(c) |
|
Definition
|
|
Term
| A combo of amoxicillin and gentamycin |
|
Definition
|
|
Term
| griseofulvin and ketoconazole |
|
Definition
|
|
Term
|
Definition
|
|
Term
flucytosine + amphotericin B
cephalosporin + norfloxacin |
|
Definition
|
|
Term
| 28 yo M dxd with HIV- best drug combo |
|
Definition
| AZT + 3 protease inh + acyclovir |
|
|
Term
| 21 yo F with non-drug resistant TB. what is teh best short term tx combo |
|
Definition
| isoniazid+ rifampin + ethambutol |
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