Term
| Give an example of a drug which works by 0-order kinetics? |
|
Definition
| Alcohol (constant amount of drug eliminated regardless of dose) |
|
|
Term
| What does it mean for a drug to be metabolized by 1st order kinetics? |
|
Definition
| The drug is eliminated proportional to dose |
|
|
Term
| How many half lives until a drug reaches steady state? |
|
Definition
|
|
Term
| What is the bioavailability of an intravenous drug? |
|
Definition
|
|
Term
| Name some INHIBITORS of P-450? |
|
Definition
| ketoconazole, erythromycin, cipro, flagyl, amiodarone, verapamil |
|
|
Term
| Name some INDUCERS of P-450? |
|
Definition
| EtOH, cigarette smoke, dilantin, WARFARIN |
|
|
Term
| In the treatment of gout, name the medication which binds tubulin and inibits migration? |
|
Definition
|
|
Term
| In the treatment of gout, name a xanthine oxidase inhibitor? |
|
Definition
|
|
Term
| In the treatment of gout, name a medication which INCREASES renal secretion of uric acid? |
|
Definition
|
|
Term
| Important side effect of PHENERGAN? |
|
Definition
tardive dyskinesia
(treat with benadryl) |
|
|
Term
| Mechanism of action of metoclopramide? |
|
Definition
| Dopamine receptor blocker (used to increase gastric/gut motility) |
|
|
Term
| Mechanism of action of zofran? |
|
Definition
| Serotonin receptor inhibitor |
|
|
Term
| Mechanism of action of DIGOXIN? |
|
Definition
inhibits Na/K ATPase and increases myocardial Ca
(slows AV conduction, but increases atrial contraction rate, also an inotrope) |
|
|
Term
| Medication proven to reduce post-op MI (and A fib)? |
|
Definition
|
|
Term
| Mechanism of action of leuprolide? |
|
Definition
| Is an analogue of GnRH and acts continuously, thereby inhbiting release of LH and FSH (which depend on intermittent GnRH release) |
|
|
Term
| Used to close a patent PDA? |
|
Definition
|
|
Term
| Pathophysiology of NSAID related ulcer formation? |
|
Definition
| NSAIDS inhibit prostaglandin synthesis, leading to decreased mucous and bicarbonate secretion, increased acid production |
|
|
Term
| Pathophysiology of malignant hyperthermia? |
|
Definition
| altered calcium regulation in skeletal muscle |
|
|
Term
| First sign of malignant hyperthermia in an intubated patient? |
|
Definition
|
|
Term
| Treatment of malignant hypertheermia? |
|
Definition
Dantrolene
(Hyperventilation, end surgery if able) |
|
|
Term
| Important side effect of tacrolimus and cyclosporine? |
|
Definition
| renal dysfunction (Nephrotoxic) |
|
|
Term
| Mechanism of action of Gleevec? |
|
Definition
| tyrosine kinase inhibitor, active against BCR-ABL |
|
|
Term
| Depolarizing paralytic used? |
|
Definition
|
|
Term
| Why is succinylcholine contraindicated in burn patients? |
|
Definition
|
|
Term
| Mechanism of action of Aspirin? |
|
Definition
| IRReversibly binds cyclooxygenase |
|
|
Term
| Duration of action of Aspirin? |
|
Definition
| 7 days (life of a platelet) |
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