Term
| What is the definition of drug abuse? |
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Definition
| the non-medical use of a substance for any of the following reasons--psychic effect, dependence, or suicide attempt/gesture |
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Term
| What is self administration? |
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Definition
| the end result of drug-seeking behavior; used in animal models |
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Term
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Definition
| can be stated in two ways: 1) the effect of a specific dosage decreases with repeated administration, or 2) a higher dosage is needed to produce the same effect with reapeated administration |
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Term
| What is dispositional tolerance? |
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Definition
| tolerance due to changes in the pharmacokinetic properties of the drug (absorption, distribution, metabolism and/or elimination) |
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Term
| What is pharmacodynamic tolerance? |
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Definition
| tolerance due to adaptive changes in teh affected systems |
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Term
| Downregulation of receptors is an example of what type of tolerance? |
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Definition
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Term
| What is behavioral tolerance? |
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Definition
| an individual alters their behavior in order to adapt or compensate for the presence of a drug |
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Term
| What word should replace the term "addiction" because it is more useful in understanding the components of drug abuse? |
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Definition
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Term
| What is physical dependence? |
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Definition
| the presence of "withdrawal" or abstinence syndrome, which is characterized by signs and symptoms usually opposite to those produced by the acute administration of the drug |
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Term
| T/F Behavioral/psychological dependence can NOT occur independantly of physical dependence. |
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Definition
| false; it can occur independently of physical dependence |
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Term
|
Definition
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Term
| What kind of drug is diethylpropion? |
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Definition
|
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Term
| What type of drug is phenmetrazine? |
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Definition
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Term
| What type of drug is phentemine? |
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Definition
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Term
| Name some dissociative anesthetics. |
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Definition
| ketamine, PCP (phencyclidine) |
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Term
| Name the tryptamine hallucinogens. |
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Definition
| dimethyltryptamine, hamine, lysergic acid, psilocin, psilocybin |
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Term
| Name the phenalkylamine hallucinogens. |
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Definition
| methylenedioxyamphetamine, methylenedioxymethamphetamine |
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Term
| Name the phenethylamines hallucinogens. |
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Definition
| dimethoxymethylamphetamine (DOM), and mescaline (peyote) |
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Term
| Name some anticholinergic hallucinogens. |
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Definition
| atropine, scopolamine, ditran |
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Term
| What are the different types of hallucinogens? |
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Definition
| tryptamines, phenalkylamines, phenethylamines, anticholinergics |
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Term
| What kind of drug is alphaprodine? |
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Definition
|
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Term
| What kind of drug is anileridine? |
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Definition
|
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Term
| What type of drug is butorphanol? |
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Definition
|
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Term
| What type of drug is levorphanol? |
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Definition
|
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Term
| What type of drug is methadyl acetate? |
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Definition
|
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Term
| What type of drug is nalbuphine? |
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Definition
|
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Term
| What type of drug is pentazocine? |
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Definition
|
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Term
| What type of drug is chlordiazepoxide? |
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Definition
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Term
| What type of drug is chloral hydrate? |
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Definition
|
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Term
| What type of drug is ethinamate? |
|
Definition
|
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Term
| What type of drug is gammahydroxybutyrate? |
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Definition
|
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Term
| What type of drug is glutethiamide? |
|
Definition
|
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Term
| What type of drug is meprobamate? |
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Definition
|
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Term
| What type of drug is paraldehyde? |
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Definition
|
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Term
| What type of drugs are the aliphatic acelate? |
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Definition
|
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Term
| What type of drugs are carbon tetrachloride? |
|
Definition
| solvent, volatile intoxicant |
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Term
| What types of drugs are freon propellants? |
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Definition
| solvents; volatile intoxicants |
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Term
| What type of drug is toluene? |
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Definition
| volatile intoxicant (solvent) |
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Term
| What type of drug is trichloroethane? |
|
Definition
| volatile intoxicant (solvent) |
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Term
| What type of drug is amyl nitrate? |
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Definition
|
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Term
| What is the MOA of canabinoids? |
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Definition
| CB1 receptor in the brain, CB2 receptor in the periphery |
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Term
| Can you become dependent on canabinoids? |
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Definition
| not physically but you can become psychologically dependent |
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Term
| Can you become tolerant to canabinoids? |
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Definition
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Term
| What is the canabinoid antagonist and what is it used for? |
|
Definition
| rimonobant; treatment for obesity but causes anhedonia as a side effect |
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Term
| Can you become dpedent on CNS stimulants? |
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Definition
| mild physical dependence; definite psychological dependence |
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Term
| Can you become tolerant to CNS stimulants? |
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Definition
|
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Term
| How should you treat someone who has overdosed on a stimulant? |
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Definition
| maybe with an antipsychotic like haloperidol if they need it |
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Term
| How do you treat someone for dependence on a CNS stimulant? |
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Definition
|
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Term
| What is the MOA of dissociative anesthetics? |
|
Definition
| glutamate receptor antagonists |
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Term
| Can you have dependence on a dissociative anesthetic? |
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Definition
| life-threatening physical dependence as well as psychological dependence |
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Term
| Do you develop tolerance to ddissociative antipsychotics? |
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Definition
|
|
Term
| How do you treat OD on dissociative anesthetics? |
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Definition
|
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Term
| How would you treat withdrawal from a dissociative anesthetics? |
|
Definition
| treat seizures with benzodiazepine |
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Term
| What is the MOA of hallucinogens? |
|
Definition
| 5-HT2A receptor agonist or anticholinergic |
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Term
| Can you have dependence on hallucinogens? |
|
Definition
| no physical dependence but definate psychological dependence |
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|
Term
| Can you develop tolerance to hallucinogens? |
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Definition
|
|
Term
| What is the treatment for hallucinogen overdose? |
|
Definition
| atypical antipsychotics, preferably 5HT2A antagonists or cholinesterase inhibitor |
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Term
| Can you become dependent on opioids? |
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Definition
| yes both physically and psychologically; physical withdrawal symptoms= vasoconstriction, chills/goosebumps, cramping |
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Term
| How is opioid dependence treated? |
|
Definition
| methadone maintenence (24 hour t1/2) or buprenorphine (48 hour t1/2) |
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|
Term
| What is the MOA of sedative hypnotics? |
|
Definition
|
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Term
| Can patients become dependent on sedative hypnotics? |
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Definition
| yes life threatenning physical dependence as well as psychological dependence |
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Term
| Can patients become tolerant to the effects of sedative hypnotics? |
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Definition
|
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Term
| How are sedative-hypnotic OD treated? |
|
Definition
| benzodiazepines like flumazenil |
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Term
| How is sedative hypnotic withdrawal treated? |
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Definition
|
|
Term
| What is the antabuse used for alcoholism? |
|
Definition
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