Term
| best anti-septic coverage? |
|
Definition
| Chlorhexadine > betadine (no fungal coverage) |
|
|
Term
Anti-virals
-tx for HSV
-CMV |
|
Definition
HSV = Acyclovir
CMV = Ganciclovir |
|
|
Term
Anti TB drugs
-INH tox/prevention |
|
Definition
-hepatotox
-periph neuropathy (prevent w/B6) |
|
|
Term
|
Definition
1. hepatotox = INH, Rifamp, Pyrazinamide
2. periph neuro = INH
3. Retrobulbar neuritis = ethambultol
4. Oto/nephrotox = Streptomycin |
|
|
Term
|
Definition
1. INH = cell wall (mycolic acids)
2. Rif = RNA polymerase
3. Pyrazinamide = cell wall (arabinogalactan)
4. Ethambutol = inhibit FA synth
5. Streptomycin = small ribo sub-unit (30S) |
|
|
Term
Amphotercin
how to diminish SE? |
|
Definition
liposomal form
-renal tox (DI)
-hepatotox, anemia, hypoK |
|
|
Term
|
Definition
*anidulafungin*
-cell wall glucan inhibitor
-few SE, undergoes spont degredation |
|
|
Term
|
Definition
|
|
Term
|
Definition
fungal p450 inhibitor
==| ergosterol |
|
|
Term
|
Definition
| Itraconazole = more broad specturm |
|
|
Term
| invasive aspergillposis tx |
|
Definition
|
|
Term
| Drug dose adjustment @ peak vs trough too high |
|
Definition
peak = dec amount
trough = dec frequency |
|
|
Term
|
Definition
|
|
Term
|
Definition
ferredoxin = active metab
-O2 radical formation |
|
|
Term
| Common clinda indications |
|
Definition
-Asp pna (anaerobic coverage)
-C perfringens |
|
|
Term
| drug combo to avoid w/macrolides? |
|
Definition
macro + statin
-periph neuropathy |
|
|
Term
|
Definition
erythrom
azithro
clarithromycin |
|
|
Term
|
Definition
QT prolongation
Nausea w/PO
Cholestasis w/IV |
|
|
Term
Amingolycoside
-resistance mech |
|
Definition
| decreased active transport |
|
|
Term
|
Definition
reversible nephrotox
irreversible ototox |
|
|
Term
|
Definition
*-floxacin*
-tendon rupture
-periph neuro |
|
|
Term
| what facilitates aminoglycoside uptake? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| change in cell wall binding site |
|
|
Term
|
Definition
| 2/2 vanc -->histamine release |
|
|
Term
| % w/penicillin allergy that have cephalosporin allergy? |
|
Definition
|
|
Term
| coverage differences between cephalosporin generations |
|
Definition
1st = GPCs. No CNS penetration
2nd = GPC + GNR
3rd = GNRs |
|
|
Term
| list first gen cephalosporins |
|
Definition
|
|
Term
|
Definition
cefoxitin
cefotetan
cefuroxime |
|
|
Term
|
Definition
|
|
Term
|
Definition
oxa, naf, methicillin
-beta lactamase resistant |
|
|
Term
|
Definition
ampicillin
amoxicillin
(have enerococci coverage) |
|
|
Term
| combo amino-penicillin drugs |
|
Definition
*beta-lactamase inhibitors*
ampicillin + sUlbactam = Unasyn
amoxicillin + clavulanic acid = Augmentin |
|
|
Term
| extended spectrum penicillins = |
|
Definition
| ticarcillin, piperacillin |
|
|
Term
| Zosyn = piperacillin + sulbactam |
|
Definition
|
|
Term
| what abx are ineffective in presence of beta-lactamase? |
|
Definition
PCN
cephalosporin
monobactams
carbapenems |
|
|
Term
|
Definition
| dec active transport into cell |
|
|
Term
| fluoroquin resistance mech? |
|
Definition
| DNA gyrase mutation = can't bind |
|
|
Term
| macrolid resistance mech? |
|
Definition
| ribosomal subunit mutation= can't bind |
|
|
Term
|
Definition
nitroreductase gene/plasmid = drug is taken up and reduced w/out formation of damaging nitro-radicals
*nitro or O2 radicals??* |
|
|
Term
| MRSA / VRE resistance mech? |
|
Definition
| alterations in cell wall binding protein |
|
|
Term
|
Definition
|
|
Term
| bugs that use beta-lactamse for MDR |
|
Definition
klebsiella
serratia
enterobacter |
|
|
Term
Inhibitors of cell wall synth
-list |
|
Definition
Penicillins
Cephalosporins
Carapenems
Monobactams
Vanc |
|
|
Term
| Small subunit ribosome inhibitors |
|
Definition
tetracyclines
aminoglycosides (IRREV)
Linezolid (IRREV) |
|
|
Term
| Large ribosome subunit inhibitors |
|
Definition
Macrolides
Clinda
Chloramphenicol
Synercid (irrev) |
|
|
Term
|
Definition
|
|
Term
| RNA polymerase inhibitors |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
PABA analogue
-inhibits purine synth |
|
|
Term
|
Definition
DHFR inhibitor
-inhib purine synth |
|
|
Term
| What abx are baceriostatic ? |
|
Definition
chloramphenicol
Tetracycline
Clinda
Macrolides
Bactrim
*all others = bacteriocidal* |
|
|
